You can create a vacation auto-reply or an out-of-office message in your Connect G Suite Mail account using the "vacation responder".
In general, your reply is only sent once to people who email you. However, if the same person contacts you again after four days and your vacation responder is still on, Google will send another vacation response to remind the person that you're away from your email. Your vacation response will start over each time you edit it, so if someone receives your initial vacation response, and then emails you again after you've edited the subject or body of the message, he or she will receive the edited response.
Messages classified as spam and messages addressed to a mailing list you subscribe to will not receive a vacation response.